MAPK

Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and …

OTS514 (OTS514 Hydrochloride) is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small …

(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of …

Omtriptolide, triptolide purified from the Chinese herb, is a water-soluble derivative prodrug.

Ravoxertinib hydrochloride is an orally bioavailable and selective inhibitor for ERK kinase activity (IC50: 6.1 …

PERK-IN-2 is a potent inhibitor of PERK(IC50 of 0.2 nM).

LY2452473 is an orally bioavailable and selective androgen receptor modulator.

R1487 Hydrochloride (R1487 (Hydrochloride)) is an orally bioavailable and highly selective inhibitors of p38α.

Sorafenib (Bay 43-9006) is a multikinase inhibitor that inhibits Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, …

CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.

GW806742X is an inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL …

SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).

AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).

LXH254 is a potent C-Raf and B-Raf inhibitor.

Honokiol (NSC-293100) is the active principle of magnolia extract. It inhibits the activation of Akt …

Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside …

HI-TOPK-032 is an effective and specific inhibitor of TOPK.

NMS-P715 is a highly selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).

Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and …

ETC-206 is a selective inhibitor of MNK1 and MNK2 (IC50s: 64 nM and 86 nM).