ANG2 Protein, Rhesus macaque, Recombinant (hFc)
Ref. TM-TMPJ-01435
1mg | 3.051,00 € | ||
10µg | 147,00 € | ||
50µg | 428,00 € | ||
500µg | 2.034,00 € |
Información del producto
- ANG-2, Angiopoietin-2, AGPT2, angiopoietin 2, Tie2-ligand, ANG2, angiopoitin 2, angiopoietin-2B, ANGPT2, angiopoietin-2a
Angiopoietin-2 (Ang-2; also ANGPT2) is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Both Ang-2 and the related Angiopoietin-1 (Ang-1) are ligands for the receptor tyrosine kinase Tie-2. While Ang-1 is a potent Tie 2 agonist, Ang-2 may act as either a Tie-2 antagonist or agonist, depending upon its state of multimerization. The higher the order of oligomer, the more effective Ang-2 becomes as a Tie-2 agonist. The short isoform appears to block the binding of either Ang-1 or full-length Ang-2 to Tie-2. Ang-2 functions as a pro-angiogenic factor, although it can also induce EC death and vessel regression. Upon its release from quiescent EC, it regulates vascular remodeling by promoting EC survival, proliferation, and migration and destabilizing the interaction between EC and perivascular cells. In addition, ANG-2 is strongly expressed in the vasculature of many tumors and it has been suggested that ANG-2 may act synergistically with other cytokines such as vascular endothelial growth factor to promote tumor-associated Angiogenesis and tumor progression.
Propiedades químicas
Consulta técnica sobre: TM-TMPJ-01435 ANG2 Protein, Rhesus macaque, Recombinant (hFc)
Si desea solicitar un presupuesto o realizar un pedido, por favor añada los productos deseados a su carrito y solicite un presupuesto o pedido desde el carrito. Es más rápido, más barato, y podrá beneficiarse de los descuentos y las ventajas disponibles.