Anti-Cyclin D1 antibody
Ref. 3D-CRB2005024
| 20µg | 252.00 € | ||
| 100µg | 455.00 € |
Product Information
Cyclin D1 is a key regulator of cell proliferation and its expression and accumulation within cells is under tight control. Cyclin D1 is the regulatory subunit of cyclin-dependent kinases 4 and 6. These activated cyclin dependent kinases then phosphorylate the retinoblastoma protein (Rb) and drive G1 to S phase progression. Cyclin D1 promotes cell proliferation through interaction with transcription factors such as the oestrogen receptor and specificity protein 1 (Sp1). Cell proliferation is extremely sensitive to altered levels of cyclin D1, with even modest changes in its expression having noticeable effects on cell cycle progression.
Cyclin D1 is a proto-oncogene and its overexpression is one of the most frequent alterations seen in multiple cancer types.
Data: Newcastle University Western blot analysis of whole cell extract of human prostate adenocarcinoma (PC-3) and human osteocarcinoma (U-2 OS) (12µg).
Lane 1: Human PC-3 protein (12µg).
Lane 2: Human U-2 OS protein (12µg).
Chemical properties
Technical inquiry about: 3D-CRB2005024 Anti-Cyclin D1 antibody
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