(-)-N-Trifluoroacetyl-1-aminoindan

CAS: 155666-94-7

Ref. TR-T895945

Product Information

• Name: (-)-N-Trifluoroacetyl-1-aminoindan
• Synonyms: N-[(1R)-2,3-dihydro-1H-inden-1-yl]-2,2,2-trifluoroacetamide
• CAS: 155666-94-7

Description

Applications (-)-N-Trifluoroacetyl-1-aminoindan is an intermediate in the synthesis of (3R)-2,3-Dihydro-3-(2-propyn-1-ylamino)-1H-inden-1-one (D449765), which is a building block in the preparation of Rasagiline (R126000), which is a selective irreversible MAO-B inhibitor. Rasagiline is also an Antiparkinsonian agent.
References Rabey, J.M., et al.: Clin. Neuropharmacol., 23, 324 (2000); Glezer, S., et al.: Eur. J. Pharmacol., 472, 173 (2003); Youdim, M.B.H., et al.: Biochem. Pharmacol., 66, 1635 (2003); Chen, J.J., et al.: J. Clin. Pharmacol., 45, 878 (2005)

• Brand: TRC

Chemical properties

• Molecular weight: 229.198
• Formula: C₁₁H₁₀F₃NO
• Color/Form: Neat
• InChI: InChI=1S/C11H10F3NO/c12-11(13,14)10(16)15-9-6-5-7-3-1-2-4-8(7)9/h1-4,9H,5-6H2,(H,15,16)/t9-/m1/s1
• InChI key: InChIKey=YUPHAYFQAVLCRV-SECBINFHSA-N
• SMILES: O=C(N[C@@H]1CCc2ccccc21)C(F)(F)F