MRTX-1257
CAS: 2206736-04-9
Ref. TM-T16143
1mg | 63.00 € | ||
2mg | 89.00 € | ||
5mg | 128.00 € | ||
10mg | 215.00 € | ||
25mg | 364.00 € | ||
50mg | 547.00 € | ||
100mg | 783.00 € | ||
1ml*10 (DMSO) | 172.00 € |
Product Information
- MRTX1257
MRTX-1257 is a selective, irreversible, and covalent inhibitor of KRAS G12C. It has an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells. MRTX1257 demonstrated 31% bioavailability in the mouse, with free fraction exposures well above the cellular potency In a PK/PD experiment, 77% target engagement.
Chemical properties
Technical inquiry about: TM-T16143 MRTX-1257
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